Abstract: Taking a long span continuous rigid frame bridge with high piers as the research object, the overall spatial finite element model of the bridge was established by finite element software of Midas to analyze its self-vibration characteristics, and response spectrum analysis and elastic time-history analysis were further carried out. A bilinear hysteretic curve was also adopted to simulate the friction pendulum bearing so as to carry out a nonlinear time history analysis and an anti-seismic performance analysis for the bridge. The analysis results show that the basic frequency of the bridge structure is reduced and the self-vibration duration is prolonged by the friction pendulum bearing, which has positive effect on the anti-seismic performance; The deployment of the bearing significantly can reduce the internal force response and the displacement response, and greatly affect the seismic response in the direction along the bridge. After isolation, the calculated moments of the piers are less than the initial yielding moment under the E2 seismic load, which indicates that the piers are in an elastic state and the bridge is capable of meeting the given anti-seismic requirements.