Abstract: To analyze the land-use change in the Shule River Basin, based on multiple satellite remote sensed data (1980, 2000 and 2013) and topographic map, this study picks the midstream of the Shule River as the study area and utilizes the human-computer interaction interpretation, spatial analysis method and mathematical statistics function to obtain the current land use status and land use transfer matrix of the basin, which contributes to the systematical analysis of land use structure dynamic change in the past 34 years. The results showed as follows: ① In the past 34 years, unused land has distributed most widely in the midstream of the Shule River, followed by grass land, arable land, forest land, building and water area accounting less than 4% of study area; ② The arable land in the midstream of the Shule River had increased significantly but sharply shrinkage of water area was found in the past 34 years; ③ The change intensity and direction of each landscape type in the basin was different, and there was a degradation trend in ecological function. The change intensity of landscape pattern under pure natural ecological system had an increasing trend in recent years, and the influence intensity of human activities showed a strengthening trend.