Abstract: With the rapid development of urbanization, the problem of slope stability caused by land filling has aroused increasing attention in engineering field. Construction solid waste (CSW) slopes are often composed of different attribute discarded soil, and have characteristic of multilayer structure. Aiming at the feature of “thick in middle, thin on both sides” of slope profile in the sliding direction, a concept of shear strength contribution rate is proposed to identify the optimal sequence of land filling. The evolution processes of pore water pressure and stability of different multilayer slopes before and after rainfall are studied based on the theory of saturated-unsaturated seepage and the principle of rigid body limit equilibrium. The results show that stability of slopes increase when CSW of larger friction angle is filled at the bottom of slope and the CSW of large cohesion is filled at the top of slope. In addition under rainfall infiltration, degradation of stability and hysteresis of appearing time of smallest safety factor vary due to the stratification differences from multilayer structures of the slope. If highly permeable CSW (e.g., gravel) is filled prior to the landfill construction, the discharge of water in the slope can be enhanced and the slope stability will also rise more rapidly.