Abstract: Plateau lakes have poor natural, geographical and climatic conditions, and locate in sparsely populated areas, so it is very difficult to obtain basic data in the field. In order to solve the problems of monitoring, evaluating and researching on water resources, water environment and water disasters in the plateau lakes, this paper takes the salt lake basin in the Hoh Xil of Qinghai Province as the research area, an aerial-space-earth-water integrated stereoscopic monitoring system was established to obtain all-round basic data of the salt lake. The area, water level, volume and potential overflow path of the lake were analyzed and predicted. The results show that the area of salt lakes increased from 147.41 km2 in January 2015 to 196.27 km2 in December 2018. Over the four-year period, the area increased by 48.86 km2, with a growth rate of 24.9%. The volume of lakes increased from 1.9116 billion m3 to 3.3878 billion m3. Over the four-year period, the growth volume reached 1.4762 billion m3, with a growth rate of 43.6%. By establishing an aerial-space-earth-water integrated stereoscopic monitoring system for plateau lakes, high-precision basic data of plateau lakes can be obtained to provide data foundation and decision support for water resources management and ecological environment protection in the Hoh Xil salt lake basin.