Abstract: In consideration of the connotation of water safety and the water situation in Zhejiang Province, we established a comprehensive evaluation index system in five dimensions: water resources, water economy, water ecology, water environment and water engineering. On the basis of the panel data from 2008 to 2016 of each district and city in Zhejiang Province, we analyzed the water safety state and spatial-temporal variation characteristics. The results suggested that:(1) From the perspective of time, the water safety state of Zhejiang Province has experienced three stages during the study period, i.e., steady growth period from 2008 to 2010, disorder fluctuation period from 2008 to 2013 and rapid growth period from 2013 to 2016. (2) From the perspective of space, the spatial heterogeneity of water safety state is significant and shows the characteristics of "strong in northeast Zhejiang, weak in southwest Zhejiang", which is in accordance with the pattern of economic and social development in the province. (3) From the perspective of dynamic change, the regional difference in the water safety state has gradually become smaller. Besides, the optimization speed shows a pattern of “slow in northeast Zhejiang, fast in southeast Zhejiang”. In this paper, we also put forward relevant countermeasures and suggestions to improve the state of water safety in Zhejiang Province and achieve a balanced and full development of provincial water safety system.