Abstract: Reservoir sediment ejection regulation is an important measure to ensure the comprehensive benefits of reservoirs. Based on the measured data of water and sediment in the main hydrological stations of the Three Gorges Reservoir (TGR) from 2003 to 2018, this paper analyzed the law of water and sediment in the reservoir area. According to the layout of hydrological stations along the river, the reservoir area was divided into three sections, and the correlation between sediment transport ratio and different influencing factors in different sections was discussed by stepwise regression, and the formulas of sediment transport ratio in different reservoir sections were established. The results showed that: (1) the main influencing factors for sediment transport ratio from Cuntan to Qingxichang section were discharge variation coefficient and water-sediment coefficient, the main influencing factors for Qingxichang to Wanxian section were flood detention coefficient and sediment concentration, and the main influencing factors for Wanxian to Miaohe section were flood detention coefficient and discharge. (2) Based on the formula of sediment transport ratio of different reservoir sections, a new idea to improve the efficiency of sediment discharge was put forward, namely lowering the water level when the sand peak transporting to Qingxichang station, and continuing to increase the discharge when the sand peak transporting to Wanxian station. The research results can provide reference for the optimal operation of the Three Gorges Reservoir.