Abstract: The geological disasters of landslides in Guizhou Province have a wide range of distribution and high frequency, and they have always received widespread attention. Therefore, based on the typical landslide deformation characteristics in Guizhou Province, studying its sliding mechanism is of great significance for understanding landslide formation and early warning of landslides. For this reason, based on the geological observation and formation characteristics of the field landslide of the western and northern Guizhou Province, this paper designed 6 sets of sandbox models with different combinations of stratum dip and brittle-ductile layer thickness. Results showed that the dip angle of the formation and the thickness of the brittle-ductile layer had obvious control effects on evolution of the landslide. It further revealed that creep was mainly formed under the condition of low stratum dip, and there were large differences in the distribution of fracture characteristics. The studies showed that the sequence of landslide evolution was to stretch and crack at the front edge - then stretch and crack at the back edge - shear in the middle-then squeeze at the front edge - and finally slowly creep and stop sliding. Results of this test are compared with the landslides in Qinglong County, and they have good similarities.