Abstract: The unique landform and climate characteristics of Guizhou Province are the main causes for frequent flood disasters and serious flood losses.It is urgent to systematically plan a provincial flood control and disaster reduction system with strengthening flood regulation and risk management, so that the losses caused by floods can be minimized.In this study, an in-depth analysis was carried out to unveil flood and waterlogging characteristics in Guizhou Province, from which the weaknesses of the current flood control and disaster reduction work was identified.According to the new concept of two adherings and transformation from three aspects for disaster prevention in the new era, and following the requirements for high-quality water resources development in the new era, a way for systematic flood control and disaster reduction across the province with river basin as a unit system was proposed.Diversified flood control measures were developed including unblocking channels, increasing flood storage capacity, enlarging discharge, executing joint scheduling, and controlling risks.The layout of flood control works, objects to be protected against floods, and flood protection standards were also clarified.On this basis, the key points of flood prevention work in the future were pointed out.It is suggested to build a flood control and disaster reduction system in Guizhou Province from the aspects of eliminating potential safety hazards of flood control projects, promoting flood control management of rivers, strengthening the construction of urban flood control and drainage standards, strengthening mountain flood disaster prevention and control, improving the construction of flood drainage standards in waterlogging areas, and strengthening flood dispatch and risk management.The research results can provide reference for further perfecting the ideas of flood control and disaster reduction and building a modernized flood control and disaster reduction system in Guizhou Province.