Abstract: There is a larger error in estimating the lake water storage and change through the underwater topography data which is obtained from the spatial interpolation by using measured water depth points.A multi-band combination model was established based on the Landsat series image and the measured water depth data below 12 m of the Duoersuodong Co for water depth simulation.The change in lake depth was obtained by combining with multi-temporal Landsat images, and then the water storage change was estimated from 1996 to 2016.The results indicated that the correlation coefficients of all the multi-band combination models were above 0.90,and the average absolute error was as low as 0.48 m, especially since it has much higher accuracy than the spatial interpolation for waters deeper than 12 m.In the past 20 years, Duoersuodong Co has been expanding continuously, the increasing rate of water level was approximately 0.40 m/a, and the increasing rate of water storage was approximately 0.18 km3/a.