Abstract: In order to study the seepage characteristics of fractured rock mass in the water-level fluctuation zone of reservoirs，the dry-wet cycling water-rock interaction test was carried out on dolomite in Wudongde Reservoir area.Based on the single fissure seepage test，the evolution law of seepage characteristics of fractured rock mass under the action of dry-wet cycling was studied，and the anisotropic seepage characteristics of fractured rock mass were studied by theoretical analysis method.The results showed that when the confining pressure was constant，the seepage flow of single crack increased linearly with the increase of seepage water pressure.When the seepage water pressure was constant，the seepage flow decreased exponentially with the increase of confining pressure.With the increasing of water-rock interaction period，the fracture seepage flow decreased suddenly and then slowly increased.The permeability characteristics of fractured rock mass had obvious anisotropy，the principal permeability coefficient and permeability tensor decreased，the radius of permeability ellipse increased，and the principal permeability direction remains unchanged after water-rock interaction.