Abstract: To deepen the understanding of the comprehensive impact of multiple disasters in Sichuan-Chongqing Region, and to improve the risk prevention capabilities for disasters, we analyze the spatial and temporal evolution characteristics of heatwave(HW) and heavy rainfall in Sichuan-Chongqing Region from1961to2022based on long-term observation data, using methods such as linear fitting, Pettitt test, and wavelet time-frequency decomposition.Adaptive strategies are also proposed for the coupled impacted areas.The results showed that:(1) Over the past60years, the HWs in Sichuan-Chongqing Region have become stronger, longer, and more frequent, with significant regional differences.The frequency of HWs lasting9days or more has exhibited a significant rise in the Southern Sichuan Economic Zone and the Northeast Sichuan Economic Zone to Chongqing City, while the frequency of HWs lasting3～8days has significantly increased in western Chengdu Plain Economic Zone.Since the early1990s, changes in the western Sichuan Basin have been particularly evident.(2) There are also significant regional differences in the changes of heavy rainfall.It is shown that a decrease in both the frequency and intensity of heavy rainfall has occurred in the western Chengdu Plain Economic Zone as well as the Southern Sichuan Economic Zone, while an increase has been observed in the eastern basin to Chongqing City.(3) Furthermore, there has been a notable rise in the occurrence of sudden shifts between drought and flood since the mid-1980s in the eastern basin to Chongqing City, and the combination of HWs and droughts has significantly increased since the early2000s in southern Sichuan Basin.(4) It is recommended that the Chengdu Plain Economic Zone directs its attention towards the potential consequences of frequent HWs on vulnerable population and energy supply within the mega-city.The Southern Sichuan Economic Zone should prioritize assessing the cumulative impact of persistent HWs and droughts on both the industrial and agricultural sectors.Similarly, the Northeast Sichuan Economic Zone should thoroughly evaluate the compounded effects of droughts, floods, and abrupt transitions between the two on agriculture and major programs.