Abstract: The geological environment in southwest China is complex, and landslide disasters occur frequently. Among these, landslide-generated waves chain disasters may pose a major threat to the safety of life and property of downstream residents and the safe operation of infrastructures. We take the Wangjiashan potential sliding body on Jinshajiang River as the research object. Based on the multi-phase smoothed particle hydrodynamics (MSPH) method, combined with the soil and water constitutive model, the whole process of landslide initiation, sliding body entry into water, and wave propagation is simulated. The energy loss characteristics during wave propagation were analyzed using variational mode decomposition (VMD) and Hilbert transform methods. The results show that the terrain effect is significant during the propagation of landslide-generated waves, and the energy attenuation increases rapidly with the increase of propagation distance; the local terrain has an important influence on the wave propagation path and energy distribution. The research results of this paper verify the effectiveness and reliability of MSPH combined with VMD-Hilbert transform method in landslide-generated wave simulation and energy loss analysis, and provide a theoretical basis and numerical basis for the prevention and control of landslide chain disasters.