Abstract: The Lancang-Mekong River is an important economic link and resource lifeline for the six countries along the coast.The development and utilization of water resources in the basin is generally not high, and the flood and drought disaster risks under climate change conditionsare severe.Due to the unsound mechanism of extensive consultation, joint contribution and shared benefits of water resources cooperation, insufficient degree of information sharing, and inadequate research on key technical issues, and lack of joint efforts to carry out flood control, drought relief and disaster reduction, the misunderstandings in water disputes still occur from time to time.Therefore, this paper studied the implementation plan of the Lancang-Mekong River water resources cooperation from four aspects of necessity, status, challenge and direction.The results show that the Lancang-Mekong River water resources cooperation is the general trend of the people′s aspirations and should be led by the six countries themselves.The six countries should take care of each other′s needs, respond to concerns, clarify responsibilities, rights and obligations, improve cooperation mechanisms, and strengthen information sharing and capacity building.On this basis, this paper suggested to promote joint scheduling of water projects, deepen joint research, promote infrastructure construction, and then build consensus, make up for the shortcomings, and meet challenges together.