Abstract: The comprehensive advanced geological prediction of tunnel is an effective supplement prediction to the ground surface exploration work, which can reveal the bad geological disaster source in front of the tunnel face during construction.Taking the water diversion project in central Yunnan as an example, through the comprehensive advanced geological prediction system and geological survey data analysis, the seismic wave method and the resistivity method, four sections prone to mud and water inrush disasters in the project area were detected, and the treatment scheme of advanced pre-grouting was put forward.The field verification results showed that the proposed prediction method can realize the advanced geological prediction of the unfavorable geological conditions in front of the tunnel face when the tunnel crosses the karst cave of the water-rich arer.The construction disposal technology based on the prediction results can help effectively deal with the unfavorable geologic conditions.